It has literally made me not interested and bored with everything else on T.V.
Everything I liked before hand has seemed so meaningless now. Even Fringe, which I still love, But I know in my heart that it probably isn't gonna have a strong ending or an emotional one like Lost did. Also, the way Fringe is, it is hard to get attached to the characters, just the mystery, Lost did both extremely well.
The only thing I am looking forward to is the 5th season of Dexter and The Event looks pretty interesting, but I feel I will be let down.
This is the only bad aspect of Lost in my opinion, which says amazing things.