Matthew Fox has said in an interview that the beginning of season six is "very surprising and probably fairly confusing initially to the audience."
So, what do you think it's going to be like?
I mean, if Jack and co. manage to alter the timeline (which I don't think is the case), we'll probably see them in LAX, or something like that. But that would not be REALLY surprising.
On the other hand, if we discovered that nothing was altered, it wouldn't be THAT surprising too.
I think the opening scene is going to be totally weird, probably something about Jacob/Nemesis and their kind (if there are others like them) or even Richard or Ilana and Bram's group. But something that we, as viewers won't be able to recognise,at first, so we're going like "What the hell is this?!" and we'll only know we're watching the right show when the title screen comes: LOST.