Set in Egyptian mythology is also known as Seth. Lost has a way of intertwining Egyptian and Christian stories, so I looked up the biblical Seth. He is the sone of Adam and a replacement to Adam for the killing of Abel and in Jewish stories was given the secrets of Kabbalah. Pretty hefty. Also, I found this:
...his descendants invented the wisdom of the heavenly bodies, and built the "pillars of the sons of Seth", two pillars inscribed with many scientific discoveries and inventions, notably in astronomy. They were built by Seth's descendants based on Adam's prediction that the world would be destroyed at one time by fire and another time by global flood, in order to protect the discoveries and be remembered after the destruction.
Considering all the indications of the Valenzetti equation and mankind's impending doom, the pillars present underneath the island, the protection of the island, and the ties between faith and science in this show, are the writers and producers crossing another couple of wires with Set and Seth also?