Just watching the new episode, and I have got to recognize Terry O' Quinn's acting in this episode. He is just mesmerizing, I have never been a fan of the acting on the show with the exception of Emerson, but Locke has really been outdone. Brilliant. Also a few notes as I have been watching.
1) Apparently, talking to the Locke monster makes you go on his side.
2) Ilana's last name is Dansky, which sounds Dutch or somewhere in the Netherlands, so that could be an indication as to her story.
3) Whoever first said that the hospital was important was right, because everybody seems to be ending up in the hospital which explains why Desmond ran over Locke.
One last theory, is that Desmond is orchestrating the Flash Sideways Timeline.