In the lead-up to season 6, you might well have caught this video, which joked about all of Lost's outstanding mysteries:
The video seemed to suggest that not only did Lost have many unresolved questions but that it couldn't possibly answer them all.
Only, it kind of did, at least the ones the video brought up. As I detail in this response video. You'll have to view it in HD or full-screen to read all the text, but if you're on Lostpedia, do you even need to read it?