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As Desmond has not been seen much in Season 5 but will he make a return in Season 6? Eloise Hawking has said that the island has not "finished" with him yet, this being in "316".
But on Lostpedia it shows that Desmond will be making no appearance in Season 6 -
S1 - S2 - S3 - MP - S4 - S5 - S6