Tranquilizer darts were used twice off Island to attack Sayid, and once on the Island to attack the survivors.
After Hurley's break out, he and Sayid visited a safe house. There they were attacked. Sayid killed two men in a lengthy fight, but not before he was shot with an anesthetizing dart, which rendered him unconscious a moment later. ("Because You Left") He was unconscious for 42 hours and it was said he had the equivalent of three doses of horse tranquilizer in his system. ("The Little Prince")
Tony out cold
In the absence of The Man in Black, Widmore's team attacked his recruits with tranquilizer darts. Jin, Sawyer, Kate , Claire, Sayid, and the rest of the group were struck by the darts and all passed out. Widmore's team stepped amongst the bodies until they found Jin, and Zoe said to take him. ("The Package")
- The tranquilizer pistol that Tony tried to shoot Sayid with, which is a Palmer Cap-Chur #1400C- Short Range Projector, is breech-loaded and only capable of a single shot before having to be reloaded. He fired two shots, then Sayid fired two shots.