His picture was the only one that is not a stock-photo.
So far, an actor playing Mittelwerk has appeared in the Rachel Blake videos and Hanso commercials, and it can be assumed that the same actor appeared in three voice recordings featuring Mittelwerk
Although, one of the recordings was entirely in Korean, and it is unknown who the actor is playing Mittelwerk, and if he can speak Korean or not.
Maybe when he forced Hanso out, he ignored the existence of the DHARMA Initiative. The scientists left on the island (The Others) have gone completely insane in the meantime.
Werner could also be a reference to Werner syndrome, a genetic disease (on chromosome 8) that causes premature aging and death, which could be consistent with Mittelwerk's role in the Hanso Foundation's Life Extension Project. Werner syndrome is recessive, meaning it is unlikely that Mittelwerk himself has the disease, however he does look somewhat older than the early to mid-40's implied by the Hanso Foundation website.
This may also be referenced by Mittelwerk's mother dying of a rare genetic disorder, as mentioned in his bio.
Werner is possibly a reference to Wernher von Braun, the German rocketry pioneer who was the lead designer of the V-2 rocket. A fictionalized Wernher von Braun, "Professor von Braun" is a leading character in the 1950s sci-fi dystopia film Alphaville, as written and directed by Jean-Luc Godard. The film--with its consideration of totalitarianism, the role of emotion in confronting "the modern," the inevitable failures of utopias and the potential diabolical uses of computers--would seem to echo some of the tropes of Lost.
Werner might also be a reference to Werner Erhard (of the EST training). Erhard was a used-car salesman who went on to found EST which survives in a different form today.
Mittelwerk is Valenzetti. Both of them have a doctorate (of which is unknown), yet none of them have any records of them ever attending any institutions!
Mittelwerk was the Economist. He was also the one who helped Ben Linus, Amy/Amelia and some others to perpetrate their scheme that lead to the purge and the events thereafter. Mittelwerk was responsible for aquiring the Galaga for Ben's "Dharma" group. He was also the one who brought the virus/toxins to the island that were used to commit the purge of Horace Goodspeed's Dharma group. He was on Ben's hit list when Ben used Sayid as his tool to clean up his own mess.