St. Francis Hospital, in Iowa, is the hospital where:
- Kate's mother Diane Janssen was hospitalized
- Kate's sweetheart Tom Brennan was employed as a physician.
- There is a real St. Francis hospital on Oahu, the filming location of the show.
- There is also a real St. Francis Hospital in Waterloo, Iowa. Possibly the hospital Tom worked in?
- Episode "Born to Run". Includes plot synopsis of events at St. Francis Hospital